The primary role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor. Activated, AMPK acts to restore energy homeostasis by promoting ATP-producing catabolic pathways while inhibiting energy-consuming processes. In non-canonical pathways, AMPK senses the availability of glucose, glycogen or fatty acids and as a result, it senses damage to lysosomes and nuclear DNA. Overall, the role of AMPK can be observed in cancer, obesity, diabetes, and nonalcoholic steatohepatitis (NASH) thus making it a focus area for therapeutic considerations.
MBL International’s AMPK kinase assay kit (CY-1182) is highly cited. The AMPK kinase assay kit can be used to measure the activity of AMPK for 96 assays. Applications of the kit include screening activators or inhibitors of AMPK, evaluating the effects of pharmacological agents on AMPK in vitro or monitoring the effects of purification of AMPK.
Additionally, MBLI AMPK antibodies are designed to detect specific Knockout validated and phosphorylated AMPK targets in the AMPK pathway.
Information provided by MBL.
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