BeCytes Biotechnologies (previously known as Cytes Technologies) - Liver Cells, Tissue Procurement and CRO Services Provided in the UK & Europe by Caltag Medsystems
BeCytes Biotechnologies
BeCytes Biotechnologies is a biotechnological company that offers products and services (CRO) based on tissue procurement, cell isolation and cell solutions for in vitro models for research purposes.
Their main focus is the isolation and full characterisation of primary human and animal hepatic and skin cells, as well as providing different tissue explants (pathological and healthy donors).
BeCytes Biotechnologies offers an extensive portfolio of cryopreserved human and animal liver cells, including plateable and suspension hepatocytes, stellates, Kupffers, liver sinusoidal endothelial cells and sub-cellular liver fractions.
BeCytes have built a reputation for providing researchers with high-quality products and services, achieved through detailed quality management systems and validated processes. These processes focus on quality, high cell viability and safety in compliance with ethical and regulatory international standards.
Read More About the Products Available:
- Primary Human Hepatocytes
- Primary Animal Hepatocytes and Sub-Cellular Liver Fractions
- Hepatic Non-Parenchymal Cells (NPCs)
- Tissue Procurement
- CRO Services
See the Products Available:
Primary Human Hepatocytes
BeCytes Biotechnologies hold a large stock of hepatocytes and perform new isolations every month of human hepatocytes available in 3 different formats: cryopreserved plated, cryopreserved in suspension, cryopreserved plateable.
Hepatocytes in suspension are cultured in suspension and mostly, they are not able to form a confluent monolayer on collagen-coated plates which is advantageous for certain research scenarios.
The most accurate representation of in vivo cellular function and characteristics can be achieved with plateable hepatocytes. BeCytes Biotechnologies cryopreserved human plateable hepatocytes are qualified by their ability to maintain a confluent monolayer (85% confluency) for at least five days.
Their human hepatocytes maintain morphology and function over long periods, and are supplied with:
- Demographic and clinical donor profile
- Viability and morphology assessment
- Culture protocols
BeCytes Biotechnologies also provides the optimal media for the culture of these human hepatocytes.
See All Primary Human Hepatocytes See Media for Human Hepatocytes
Primary Animal Hepatocytes and Sub-Cellular Liver Fractions
BeCytes Biotechnologies also provides cryopreserved animal hepatocytes which are produced with the same methodology used in the isolation of human hepatocytes.
Primary Animal Hepatocytes and Sub-cellular liver fractions (Microsomes, Cytosol and S9 fraction) are model systems often used for a variety of in vitro screenings and analyses before clinical studies in human and animal health & environmental toxicology.
While animal hepatocytes in suspension are important for short-term metabolism studies, plated animal hepatocytes are perfect for the studies of long-term metabolism or evaluation of drug candidates to investigate drug-drug interactions.
BeCytes' dog beagle, monkey cynomolgus, rat and minipig hepatocytes are model systems frequently used in vitro screening methods. They closely match the physiology in vivo and contribute to the identification of safety issues early in the drug development pipeline.
BeCytes Biotechnologies has hepatocytes from a range of species available:
- Fish: Atlantic Salmon, Carp, Rainbow Trout
- Dog: Beagle
- Chicken (Gallus)
- Monkey: Cynomolgus
- Duck
- Equine (Horse)
- Göttingen Minipig
- Mouse: CD-1
- Porcine (pig):Landrace
- Rabbit: New Zealand White Rabbit
- Sheep
- Turkey
See All Primary Animal Hepatocytes See Media for Animal Hepatocytes
Sub-Cellular Liver Fractions:
BeCytes Biotechnologies offers a selection of sub-cellular liver fractions: Microsomes, Cytosol and S9, from a variety of species:
- Fish: Atlantic Salmon, Carp, Rainbow Trout
- Dog: Beagle
- Bovine
- Mouse: CD-1, Field
- Chicken
- Monkey: Cynomolgus
- Göttingen Minipig
- Goat
- Equine (Horse)
- Quail
- Rat
- Sheep
- Turkey
Hepatic Non-Parenchymal Cells (NPCs)
Hepatic non-parenchymal cells (NPCs) represent about 30% of the liver and are specialised cells which interact with hepatocytes. NPCs present organotypic hepatocyte-NPC interactions via direct contact or paracrine signalling and forming a functional hepatic unit.
Among their many functions, NPCs play an important role for liver regeneration as well as recovery from inflammatory liver injury and scaring.
Advanced liver models, including those with in vivo-like environments and liver co-cultures, are essential for accurate predictive responses in studying liver physiology/pathology and conducting drug screenings, offering increased sensitivity and the ability to manipulate various conditions and analyse multiple parameters.
BeCytes Biotechnologies offers:
- Hepatic stellate cells (HSCs)
- Kupffer cells (KC)
- Liver Endothelial cells (LEC) and Liver Endothelial sinusoidal cells (LSEC)
- Non-parenchymal cells
BeCytes Biotechnologies also provides the optimal media for the culture of these NPCs.
See All Hepatic Non-Parenchymal Cells See Media for NPCs
Tissue Procurement
BeCytes offers a custom tissue procurement service to acquire samples tailored to unique research requirements. BeCytes Biotechnologies has created a platform capable of coordinating the donation of human tissues and cells for biomedical research purposes, encompassing strong collaborations with national and international procurement centres, biobanks and hospitals that allow them to provide a wide range of tissue samples.
Tissue samples available include skin, lung, intestine, pancreas, kidney, brain, ovarian, liver, and rectal.
Benefits of BeCytes custom tissue procurement:
- Extensive network of biobanks, hospitals, OPOS, etc to provide a wide range of healthy and pathological tissues.
- Tissue samples available in multiple formats, such as fresh, frozen, or formalin-fixed paraffin-embedded (FFPE).
- Tailored procurement and processing of biospecimens according to the conditions needed for research.
- Access to first-hand information about the donor post medical record, where the most relevant data is reflected.
CRO Services
BeCytes offer further customised research services. Please contact us for details.