South Bay Bio

20S Proteasome (human) (untagged)

Product Code:
 
SBB-PP0005
Product Group:
 
Recombinant Proteins
Supplier:
 
South Bay Bio
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Dry Ice
Storage:
 
-80C
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20S Immunoproteasome vs. 20S Constitutive Proteasome Activity: 20S Proteasome is most active against Suc-LLVY-AMC (SBB-PS0010), Z-LLE-AMC (SBB-PS0006), and Ac-WLA-AMC (SBB-PS0008) substrates, representing physiologically relevant chymotry
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20S Immunoproteasome vs. 20S Constitutive Proteasome Activity: 20S Proteasome is most active against Suc-LLVY-AMC (SBB-PS0010), Z-LLE-AMC (SBB-PS0006), and Ac-WLA-AMC (SBB-PS0008) substrates, representing physiologically relevant chymotry

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SBB-PP0005-C05050 ug£275.00
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This product comes from: Switzerland.
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Further Information

Concentration:
Lot dependent.
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 50mM HEPES pH 7.6, 100mM sodium chloride, 1mM DTT.
Handling Advice:
Aliquot to avoid freeze/thaw cycles.
Long Description:
Protein. Human 20S Proteasome. Source: Human Erythrocytes. Formulation: Liquid. In 50mM HEPES pH 7.6, 100mM sodium chloride, 1mM DTT. Purity: >95% (SDS-PAGE). The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic complex, which is formed by the association of the barrel-shaped 20S proteasome (700kDa) and two 19S (700kDa) regulatory complexes. The 20S catalytic core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha-subunits and 2 rings are composed of 7 beta-subunits. The 20S catalytic core is able to degrade a variety of peptide substrates and poly-ubiquitinated proteins involved with apoptosis, DNA repair, endocytosis and cell cycle control.
Molecular Weight:
~700kDa
Package Type:
Plastic Vial
Product Description:
The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic complex, which is formed by the association of the barrel-shaped 20S proteasome (700kDa) and two 19S (700kDa) regulatory complexes. The 20S catalytic core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha-subunits and 2 rings are composed of 7 beta-subunits. The 20S catalytic core is able to degrade a variety of peptide substrates and poly-ubiquitinated proteins involved with apoptosis, DNA repair, endocytosis and cell cycle control.
Purity:
>95% (SDS-PAGE)
Sequence:
Human 20S Proteasome.
Source / Host:
Human Erythrocytes
TAGs:
no TAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.