Nordic MuBio

LNX1

Product Code:
 
EXA-X2341B
Product Group:
 
Peptides
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

No additional charges, what you see is what you pay! *

CodeSizePrice
EXA-X2341B50 ug£162.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Netherlands.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Show All

Further Information

Applications Description:
For use with LNX1 polyclonal antibodies (Cat. No. X2316P & X2340P).
Background:
LNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the human LNX1 protein.
Positive Control:
Protein expressed in heart, placenta, kidney, pancreas and brain.
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Synonyms:
Numb-binding protein 1; Ligand of Numb-protein X 1
UniProt:
Q8TBB1

References

1. Armbruester, V., et al. 'Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.; J. Virol. 78:10310-10319(2004).

2. Sollerbrant, K., et al. 'The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).; J. Biol. Chem. 278:7439-7444(2003).

3. Xie, Y., et al. 'Identification of a human LNX protein containing multiple PDZ domains.; Biochem. Genet. 39:117-126(2001).